関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Maleic Acid | HCID 444266 | — |
| 反応物 | Enalapril | HCID 5388962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Enalapril Maleate | HCID 5388961 | — |
反応手順
N-(1(S)-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline and acetonitrile are mixed and to this mixture is added maleic acid with heating at 70° C. and the mixture is gradually cooled to obtain N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline maleate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06518436B2 |
|---|
| 出典データセット | uspto-grants-2003_02 |
|---|
| ORD ID | ord-1b7988bdc6d94551bb08879c7e77426e |
|---|
| 出典メモ | uspto-grants-2003_02 |
|---|
