HCID 178488534, compound → HCID 178488533, compound

HRID 1059140Notes

Reaction equation

HRID 1059140 reaction equation
[NH:1]1[CH:5]=[C:4]([CH:6]([C:8]2[CH:9]=[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:11]=[CH:12][C:13]=2[O:14][CH3:15])[OH:7])[N:3]=[CH:2]1>ClCCl.[O-2].[O-2].[Mn+4]>[NH:1]1[CH:5]=[C:4]([C:6]([C:8]2[CH:9]=[C:10]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:11]=[CH:12][C:13]=2[O:14][CH3:15])=[O:7])[N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 178488534HCID 178488534, compound

Product 1

HCID 178488533HCID 178488533, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

1H-Imidazol-4-yl(4-methoxy[1,1′-biphenyl]-3-yl)methanol (0.94 g) was dissolved in dichloromethane (100 ml) and manganese dioxide (5.52 g) was added. The mixture was stirred at room temperature for 14 h, filtrated and concentrated. To the obtained residue was added ethyl acetate and the mixture was crystallized to give the title compound (0.84 g) as a colorless solid.

Workup

  1. filtrationfiltrated
  2. concentrationconcentrated
  3. additionTo the obtained residue was added ethyl acetate
  4. customthe mixture was crystallized

Sources & evidence

ORD record
ord-8c24dc90b6e347d9a67888a9af741b64
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

Loading…