HRID1059143

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74299

Benzeneboronic acid, p-chloro-

C6H6BClO2

结构：CC(C)C(O)(c1cccc(Br)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

HCID18668522

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(O)(c1cccc(-c2ccc(Cl)cc2)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

HCID18668550

未命名化合物

收率 69.9%

PROCEDURE

实验过程

By the reaction in the same manner as in Example 1-(i) using 4-chlorophenylboronic acid (0.49 g) and 1-(3-bromophenyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.04 g), the title compound (0.77 g) was obtained as a coloress solid.

WORKUP

后处理

customBy the reaction in the same manner as in Example

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5fc268f5d01f4c048a7b18de7aa20513
来源数据集: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06518257B1
来源说明: uspto-grants-2003_02

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Br[C:12]1[CH:13]=[C:14]([C:18]([C:23]2[N:24]=[CH:25][N:26]([C:28]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH:27]=2)([OH:22])[CH:19]([CH3:21])[CH3:20])[CH:15]=[CH:16][CH:17]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:16]2[CH:17]=[CH:12][CH:13]=[C:14]([C:18]([C:23]3[N:24]=[CH:25][N:26]([C:28]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)[CH:27]=3)([OH:22])[CH:19]([CH3:20])[CH3:21])[CH:15]=2)=[CH:4][CH:3]=1