4-Fluorophenylboronic acid → HCID 18668533, compound

HRID 1059145Notes

Reaction equation

HRID 1059145 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Br[C:12]1[CH:13]=[C:14]([C:18]([C:23]2[N:24]=[CH:25][N:26]([C:28]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH:27]=2)([OH:22])[CH:19]([CH3:21])[CH3:20])[CH:15]=[CH:16][CH:17]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:16]2[CH:17]=[CH:12][CH:13]=[C:14]([C:18]([C:23]3[N:24]=[CH:25][N:26]([C:28]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)[CH:27]=3)([OH:22])[CH:19]([CH3:20])[CH3:21])[CH:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 186685221-(3-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Product 1

HCID 18668533HCID 18668533, compoundYield 68.4%

Procedure

By the reaction in the same manner as in Example 1-(i) using 4-fluorophenylboronic acid (0.41 g) and 1-(3-bromophenyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.01 g), the title compound (0.71 g) was obtained as a pale-yellow solid.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-fd9d715715a242529549e74ef991aa68
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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