HRID1059147

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID292189

2-Formylphenylboronic acid

C7H7BO3

结构：CC(C)C(O)(c1cccc(Br)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

HCID18668522

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(O)(c1cccc(-c2ccccc2C=O)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

HCID18668581

未命名化合物

收率 87.1%

PROCEDURE

实验过程

By the reaction in the same manner as in Example 1-(i) using 2-formylphenylboronic acid (0.50 g) and 1-(3-bromophenyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.02 g), the amorphous title compound (0.93 g) was obtained.

WORKUP

后处理

customBy the reaction in the same manner as in Example

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-79dac8e345074856ac8b50d9535e7878
来源数据集: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06518257B1
来源说明: uspto-grants-2003_02

反应 SMILES

[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1B(O)O)=[O:2].Br[C:13]1[CH:14]=[C:15]([C:19]([C:24]2[N:25]=[CH:26][N:27]([C:29]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:28]=2)([OH:23])[CH:20]([CH3:22])[CH3:21])[CH:16]=[CH:17][CH:18]=1>>[OH:23][C:19]([C:15]1[CH:14]=[C:13]([C:4]2[C:3]([CH:1]=[O:2])=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:18]=[CH:17][CH:16]=1)([C:24]1[N:25]=[CH:26][N:27]([C:29]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:28]=1)[CH:20]([CH3:22])[CH3:21]