Pyridinium chloride → HCID 178450126, compound

HRID 1059154Notes

Reaction equation

HRID 1059154 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([C:19]3[N:20]=[CH:21][N:22](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:23]=3)([OH:18])[CH:15]([CH3:17])[CH3:16])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([C:19]3[N:20]=[CH:21][NH:22][CH:23]=3)([OH:18])[CH:15]([CH3:17])[CH3:16])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668589HCID 18668589, compound

Product 1

HCID 178450126HCID 178450126, compoundYield 80.3%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 1-(3′-fluoro[1,1′-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (2.55 g) and pyridine hydrochloride (906 mg), the title compound (1.15 g) was obtained as colorless needle crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-11ecbc2254b145bab42da6d766f233f1
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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