Pyridinium chloride → HCID 178450127, compound

HRID 1059156Notes

Reaction equation

[CH3:1][CH:2]([CH3:45])[C:3]([C:29]1[CH:30]=[C:31]([C:35]2[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:43])[F:42])=[CH:37][CH:36]=2)[CH:32]=[CH:33][CH:34]=1)([C:5]1[N:6]=[CH:7][N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1)[OH:4].Cl.N1C=CC=CC=1>>[NH:8]1[CH:9]=[C:5]([C:3]([C:29]2[CH:30]=[C:31]([C:35]3[CH:40]=[CH:39][C:38]([C:41]([F:42])([F:43])[F:44])=[CH:37][CH:36]=3)[CH:32]=[CH:33][CH:34]=2)([OH:4])[CH:2]([CH3:45])[CH3:1])[N:6]=[CH:7]1

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668571HCID 18668571, compound

Product 1

HCID 178450127HCID 178450127, compoundYield 85.9%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 2-methyl-1-[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (2.55 g) and pyridine hydrochloride (831 mg), the title compound (1.31 g) was obtained as colorless needle crystals.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-52e49235297a4c788d3cd5a665261f9a
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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