Pyridinium chloride → HCID 178450134, compound

HRID 1059157Notes

Reaction equation

HRID 1059157 reaction equation
[CH3:1][CH:2]([CH3:46])[C:3]([C:29]1[CH:30]=[C:31]([C:35]2[CH:40]=[CH:39][C:38]([O:41][C:42]([F:45])([F:44])[F:43])=[CH:37][CH:36]=2)[CH:32]=[CH:33][CH:34]=1)([C:5]1[N:6]=[CH:7][N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1)[OH:4].Cl.N1C=CC=CC=1>>[NH:8]1[CH:9]=[C:5]([C:3]([C:29]2[CH:30]=[C:31]([C:35]3[CH:36]=[CH:37][C:38]([O:41][C:42]([F:43])([F:44])[F:45])=[CH:39][CH:40]=3)[CH:32]=[CH:33][CH:34]=2)([OH:4])[CH:2]([CH3:1])[CH3:46])[N:6]=[CH:7]1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668527HCID 18668527, compound

Product 1

HCID 178450134HCID 178450134, compoundYield 170.3%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 2-methyl-1-[4′-(trifluoromethoxy)[1,1′-biphenyl]-3-yl]-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (3.63 g) and pyridine hydrochloride (1.22 g), the title compound (3.76 g) was obtained as colorless needle crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-514caae71e7241f8a3a9cc4ea2d171a3
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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