Pyridinium chloride → HCID 178494457, compound

HRID 1059159Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([C:19]3[N:20]=[CH:21][N:22](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:23]=3)([OH:18])[CH:15]([CH3:17])[CH3:16])[CH:9]=2)=[CH:4][C:3]=1[CH2:43][O:44][CH3:45].Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([C:19]3[N:20]=[CH:21][NH:22][CH:23]=3)([OH:18])[CH:15]([CH3:16])[CH3:17])[CH:9]=2)=[CH:4][C:3]=1[CH2:43][O:44][CH3:45]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668542HCID 18668542, compound

Product 1

HCID 178494457HCID 178494457, compoundYield 78.4%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 1-[4′-fluoro-3′-(methoxymethyl)[1,1′-biphenyl]-3-yl]-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (1.35 g) and pyridine hydrochloride (469 mg), the colorless amorphous title compound (629 mg) was obtained.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-4c594d38370e43189c4521ae03ac715c
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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