HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-methoxybenzaldehyde → 4'-Fluoro-6-methoxy[1,1'-biphenyl]-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-methoxybenzaldehyde | HCID 98662 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Sodium Carbonate | HCID 10340 | — |
| Product | 4'-Fluoro-6-methoxy[1,1'-biphenyl]-3-carbaldehyde | HCID 22391234 | 79.4% |
Reaction Steps
By the reaction in the same manner as in Example 5-(ii) using 3-bromo-p-anisaldehyde (14.0 g), 4-fluorophenylboronic acid (14.6 g), 2M aqueous sodium carbonate solution (260 ml) and tetrakis(triphenylphosphine)palladium(0) (3.76 g), the title compound (11.9 g) was obtained as white needle crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518257B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-fb2f766b406a478c8310a87370d04e38 |
| Source note | uspto-grants-2003_02 |