Pyridinium chloride → HCID 178450130, compound

HRID 1059163Notes

Reaction equation

[OH:1][C:2]([C:30]1[CH:31]=[C:32]([C:36]2[CH:41]=[CH:40][C:39]([C:42]#[N:43])=[CH:38][CH:37]=2)[CH:33]=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[C:32]([C:36]2[CH:37]=[CH:38][C:39]([C:42]#[N:43])=[CH:40][CH:41]=2)[CH:33]=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:4])[CH3:5]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668554HCID 18668554, compound

Product 1

HCID 178450130HCID 178450130, compoundYield 78%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 3′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propyl][1,1′-biphenyl]-4-carbonitrile (590 mg) and pyridine hydrochloride (111 mg), the title compound (261 mg) was obtained as colorless needle crystals.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-a86ddbd6952e49c1b45ec2256d905528
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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