Pyridinium chloride → HCID 178450137, compound

HRID 1059169Notes

Reaction equation

HRID 1059169 reaction equation
[CH3:1][CH:2]([CH3:40])[C:3]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[CH:39]=[CH:38][S:37][CH:36]=2)[CH:30]=1)([C:5]1[N:6]=[CH:7][N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1)[OH:4].Cl.N1C=CC=CC=1>>[NH:8]1[CH:9]=[C:5]([C:3]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]3[CH:39]=[CH:38][S:37][CH:36]=3)[CH:30]=2)([OH:4])[CH:2]([CH3:40])[CH3:1])[N:6]=[CH:7]1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668634HCID 18668634, compound

Product 1

HCID 178450137HCID 178450137, compoundYield 74.1%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 2-methyl-1-[3-(3-thienyl)phenyl]-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.43 g) and pyridine hydrochloride (550 mg), the title compound (585 mg) was obtained as colorless plate crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-5fab4b288e0c406db078820e82b87e8a
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

Loading…