Pyridinium chloride → 1-[3-(2-furyl)phenyl]-1-(1H-imidazol-4-yl)-2-methyl-1-propanol

HRID 1059171Notes

Reaction equation

HRID 1059171 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]([C:12]([C:17]2[N:18]=[CH:19][N:20](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:21]=2)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:9]=[CH:10][CH:11]=1.Cl.N1C=CC=CC=1>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]([C:12]([C:17]2[N:18]=[CH:19][NH:20][CH:21]=2)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668591HCID 18668591, compound

Product 1

HCID 1784501331-[3-(2-furyl)phenyl]-1-(1H-imidazol-4-yl)-2-methyl-1-propanolYield 72%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 1-[3-(2-furyl)phenyl]-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.54 g) and pyridine hydrochloride (610 mg), the title compound (597 mg) was obtained as colorless plate crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-dc5bf172250f4721b5197d6aefe3ef41
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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