HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(5-bromo-2-fluorophenyl)acetamide → N-{4-fluoro-4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(5-bromo-2-fluorophenyl)acetamide | HCID 242827 | — |
| Reactant | 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid | HCID 18668578 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | N-{4-fluoro-4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl}acetamide | HCID 18668557 | 45.2% |
Reaction Steps
By the reaction in the same manner as in Example 4-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (3.50 g), N-(5-bromo-2-fluorophenyl)acetamide (1.17 g) and tetrakis(triphenylphosphine)palladium(0) (0.17 g), the title compound (1.39 g); was obtained as a colorless amorphous powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518257B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-a8b643a422024375bff9db7df1a49821 |
| Source note | uspto-grants-2003_02 |