Pyridinium chloride → HCID 178474232, compound

HRID 1059182Notes

Reaction equation

HRID 1059182 reaction equation
[F:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:42])([C:18]3[N:19]=[CH:20][N:21](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:22]=3)[CH:15]([CH3:17])[CH3:16])=[CH:10][CH:9]=2)=[CH:6][C:5]([NH:43][C:44](=[O:46])[CH3:45])=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:42])([C:18]3[N:19]=[CH:20][NH:21][CH:22]=3)[CH:15]([CH3:16])[CH3:17])=[CH:10][CH:9]=2)=[CH:6][C:5]([NH:43][C:44](=[O:46])[CH3:45])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668616HCID 18668616, compound

Product 1

HCID 178474232HCID 178474232, compoundYield 50.6%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-{6-fluoro-4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1′-biphenyl]-3-yl}acetamide (820 mg) and pyridine hydrochloride (230 mg), the title compound (250 mg) was obtained as a colorless amorphous powder.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-3ed94047a73643eaa0772518b237da37
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

Loading…