Pyridinium chloride → HCID 178474141, compound

HRID 1059186Notes

Reaction equation

[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[C:40]([CH3:42])[CH:39]=[C:38]([NH:43][C:44](=[O:46])[CH3:45])[CH:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:41]=[C:40]([CH3:42])[CH:39]=[C:38]([NH:43][C:44](=[O:46])[CH3:45])[CH:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:5])[CH3:4]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668606HCID 18668606, compound

Product 1

HCID 178474141HCID 178474141, compoundYield 67%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-[4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-5-methyl[1,1′-biphenyl]-3-yl]acetamide (1.02 g) and pyridine hydrochloride (350 mg), the colorless amorphous title compound (410 mg) was obtained.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-1f239b3b3fde45cc877e7dfc9a2c68e2
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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