(4-bromophenyl)(1-trityl-1H-imidazol-4-yl)methanol → (4-bromophenyl) (1-trityl-1H-imidazol-4-yl)methanone

HRID 1059188Notes

Reaction equation

HRID 1059188 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[N:11]=[CH:12][N:13]([C:15]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:14]=2)[OH:9])=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:10]2[N:11]=[CH:12][N:13]([C:15]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:14]=2)=[O:9])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 18668611(4-bromophenyl)(1-trityl-1H-imidazol-4-yl)methanol

Product 1

HCID 18668547(4-bromophenyl) (1-trityl-1H-imidazol-4-yl)methanoneYield 78%

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

By the reaction in the same manner as in Example 24-(iii) using (4-bromophenyl)(1-trityl-1H-imidazol-4-yl)methanol (30.0 g) and manganese dioxide (52.6 g), the title compound (23.3 g) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-9304518f592b4a5e95518b862b43b5ef
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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