Pyridinium chloride → HCID 178474122, compound

HRID 1059190Notes

Reaction equation

[CH:1]1([C:4]([OH:45])([C:21]2[N:22]=[CH:23][N:24](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:25]=2)[C:5]2[CH:10]=[CH:9][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:20])[CH3:19])[CH:12]=3)=[CH:7][CH:6]=2)[CH2:3][CH2:2]1.Cl.N1C=CC=CC=1>>[CH:1]1([C:4]([OH:45])([C:21]2[N:22]=[CH:23][NH:24][CH:25]=2)[C:5]2[CH:6]=[CH:7][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:20])[CH3:19])[CH:12]=3)=[CH:9][CH:10]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668521HCID 18668521, compound

Product 1

HCID 178474122HCID 178474122, compoundYield 38.8%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-[4′-[cyclopropyl(hydroxy)(1-trityl-1H-imidazol-4-yl)methyl][1,1′-biphenyl]-3-yl]acetamide (946 mg) and pyridine hydrochloride (334 mg), the colorless amorphous title compound (216 mg) was obtained.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-8072eeb9d0e54f1182f76c41909f598b
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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