HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-N-methylbenzamide → 4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl[1,1'-biphenyl]-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-N-methylbenzamide | HCID 4294170 | — |
| Reactant | 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid | HCID 18668578 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl[1,1'-biphenyl]-3-carboxamide | HCID 18668539 | 32.9% |
Reaction Steps
By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (3.44 g), 3-bromo-N-methylbenzamide (1.10 g) and tetrakis(triphenylphosphine)palladium(0) (0.21 g), the title compound (1.00 g) was obtained as a pale-yellow amorphous powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518257B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-780ac5f727c245f39a81eb2929c0f613 |
| Source note | uspto-grants-2003_02 |