Pyridinium chloride → HCID 178464754, compound

HRID 1059203Notes

Reaction equation

[CH2:1]([NH:3][C:4]([C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([OH:46])([C:22]3[N:23]=[CH:24][N:25](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:26]=3)[CH:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)[CH:9]=[CH:10][CH:11]=1)=[O:5])[CH3:2].Cl.N1C=CC=CC=1>>[CH2:1]([NH:3][C:4]([C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([OH:46])([C:22]3[N:23]=[CH:24][NH:25][CH:26]=3)[CH:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)[CH:9]=[CH:10][CH:11]=1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668657HCID 18668657, compound

Product 1

HCID 178464754HCID 178464754, compoundYield 27.7%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-ethyl-4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1′-biphenyl]-3-carboxamide (4.00 g) and pyridine hydrochloride (1.14 g), the title compound (664 mg) was obtained as a colorless amorphous powder.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-6e8d2bce7e474c9c9224c531d1851a1f
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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