Pyridinium chloride → HCID 178457680, compound

HRID 1059205Notes

Reaction equation

HRID 1059205 reaction equation
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([NH:44][CH:45]([CH3:47])[CH3:46])=[O:43])[CH:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([NH:44][CH:45]([CH3:47])[CH3:46])=[O:43])[CH:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:5])[CH3:4]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668626HCID 18668626, compound

Product 1

HCID 178457680HCID 178457680, compoundYield 47.2%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-isopropyl[1,1′-biphenyl]-3-carboxamide (1.67 g) and pyridine hydrochloride (490 mg), the title compound (480 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-606a264bb5be4df2baa39651da93ecab
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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