Cyclopropylamine → 3-bromo-N-cyclopropylbenzamide

HRID 1059206Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[CH:11]1([NH2:14])[CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:14][CH:11]1[CH2:13][CH2:12]1)=[O:6]

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 74377Benzoyl chloride, 3-bromo-

Product 1

HCID 8961523-bromo-N-cyclopropylbenzamideYield 86.4%

Procedure

By the reaction in the same manner as in Example 45-(i) using 3-bromobenzoyl chloride (5.50 g) and cyclopropylamine (4.30 g), the title compound (5.20 g) was obtained as colorless needle crystals.

Sources & evidence

ORD record: ord-23a4c4a1574242ffa0c7806e2f6c9a9f
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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