Pyridinium chloride → HCID 178485477, compound

HRID 1059209Notes

Reaction equation

HRID 1059209 reaction equation
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[C:41]([O:42][CH3:43])=[CH:40][CH:39]=[C:38]([C:44]([NH:46][CH3:47])=[O:45])[CH:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[C:41]([O:42][CH3:43])=[CH:40][CH:39]=[C:38]([C:44]([NH:46][CH3:47])=[O:45])[CH:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:5])[CH3:4]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668603HCID 18668603, compound

Product 1

HCID 178485477HCID 178485477, compoundYield 67.4%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-6-methoxy-N-methyl[1,1′-biphenyl]-3-carboxamide (1.40 g) and pyridine hydrochloride (468 mg), the colorless amorphous title compound (576 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-5dd2e78ea9fd4615b7df14893eed7a0e
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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