Pyridinium chloride → HCID 178485442, compound

HRID 1059210Notes

Reaction equation

[F:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:42])([C:18]3[N:19]=[CH:20][N:21](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:22]=3)[CH:15]([CH3:17])[CH3:16])=[CH:10][CH:9]=2)=[CH:6][C:5]([C:43]([NH:45][CH3:46])=[O:44])=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:42])([C:18]3[N:19]=[CH:20][NH:21][CH:22]=3)[CH:15]([CH3:16])[CH3:17])=[CH:10][CH:9]=2)=[CH:6][C:5]([C:43]([NH:45][CH3:46])=[O:44])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668656HCID 18668656, compound

Product 1

HCID 178485442HCID 178485442, compoundYield 54.1%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 6-fluoro-4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl[1,1′-biphenyl]-3-carboxamide (1.64 g) and pyridine hydrochloride (559 mg), the colorless amorphous title compound (535 mg) was obtained.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-2579a35f4184416b8960a570d0a17a55
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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