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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1059219Erstellt: 25. Oktober 2026

N-(3-bromobenzyl)acetamide → N-({4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl}methyl)acetamide

https://huagongshe.com/reaction/1059219

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktN-(3-bromobenzyl)acetamideHCID 12175281—
Edukt4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acidHCID 18668578—
KatalysatorHCID 178418397HCID 178418397—
ProduktN-({4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl}methyl)acetamideHCID 1866864344,5%

Reaktionsschritte

By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (3.30 g), N-(3-bromobenzyl)acetamide (1.05 g) and tetrakis(triphenylphosphine)palladium(0) (0.18 g), the title compound (1.24 g) was obtained as a pale-yellow amorphous powder.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06518257B1
Quelldatensatzuspto-grants-2003_02
ORD IDord-02c601fc49ec4c4b9b7d34a82e078350
Quellennotizuspto-grants-2003_02