Pyridinium chloride → HCID 178474534, Verbindung

HRID 1059220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1059220
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][NH:43][C:44](=[O:46])[CH3:45])[CH:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][NH:43][C:44](=[O:46])[CH3:45])[CH:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:5])[CH3:4]

Komponenten

3

Edukt 2

HCID 10176127Pyridinium chlorideHCID 18668643N-({4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl}methyl)acetamide

Produkt 1

HCID 178474534HCID 178474534, VerbindungAusbeute 77,8 %

Versuchsvorschrift

By the reaction in the same manner as in Example 4-(iii) using N-({4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1′-biphenyl]-3-yl}methyl)acetamide (1.05 g) and pyridine hydrochloride (278 mg), the title compound (490 mg) was obtained as a colorless amorphous powder.

Aufarbeitung

  1. customBy the reaction in the same manner as in Example

Quellen und Nachweise

ORD-Eintrag
ord-2e18cb6224314cd99b7957fe9c1f93da
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06518257B1

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