Pyridinium chloride → HCID 178488576, compound

HRID 1059225Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([C:22]3[N:23]=[CH:24][N:25](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:26]=3)([OH:21])[CH:18]([CH3:20])[CH3:19])=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl.N1C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:12]=[CH:13][C:14]([C:17]([C:22]3[N:23]=[CH:24][NH:25][CH:26]=3)([OH:21])[CH:18]([CH3:20])[CH3:19])=[CH:15][CH:16]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668659HCID 18668659, compound

Product 1

HCID 178488576HCID 178488576, compoundYield 81.3%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 1-(3′,4′-dimethoxy[1,1′-biphenyl]-4-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.37 g) and pyridine hydrochloride (479 mg), the colorless amorphous title compound (660 mg) was obtained.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-1b6ec74ad3504ccd9757d7932db573d3
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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