Pyridinium chloride → HCID 178489705, compound

HRID 1059227Notes

Reaction equation

HRID 1059227 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:20]3[N:21]=[CH:22][N:23](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:24]=3)([OH:19])[CH:16]([CH3:18])[CH3:17])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.Cl.N1C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[CH:11][C:12]([C:15]([C:20]3[N:21]=[CH:22][NH:23][CH:24]=3)([OH:19])[CH:16]([CH3:18])[CH3:17])=[CH:13][CH:14]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668662HCID 18668662, compound

Product 1

HCID 178489705HCID 178489705, compoundYield 88.1%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 1-(3′-methoxy[1,1′-biphenyl]-4-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (960 mg) and pyridine hydrochloride (354 mg), the colorless amorphous title compound (483 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-226ee2ba880549c68e61e8272ef21829
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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