Pyridinium chloride → HCID 178450129, compound

HRID 1059233Notes

Reaction equation

HRID 1059233 reaction equation
[CH3:1][CH:2]([CH3:41])[C:3]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=2)[CH:30]=1)([C:5]1[N:6]=[CH:7][N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1)[OH:4].Cl.N1C=CC=CC=1>>[NH:8]1[CH:9]=[C:5]([C:3]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)[CH:30]=2)([OH:4])[CH:2]([CH3:1])[CH3:41])[N:6]=[CH:7]1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 186685632-methyl-1-[3-(2-pyridyl)phenyl]-1-(1-trityl-1H-imidazol-4-yl)-1-propanol

Product 1

HCID 178450129HCID 178450129, compoundYield 68.3%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 2-methyl-1-[3-(2-pyridyl)phenyl]-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (527 mg), pyridine hydrochloride (205 mg), the title compound (197 mg) was obtained as colorless plate crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-5bacfe7b3eed43d19bbf2f3b92ea8135
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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