Pyridinium chloride → HCID 178474121, compound

HRID 1059234Notes

Reaction equation

HRID 1059234 reaction equation
[OH:1][C:2]([C:30]1[CH:31]=[C:32]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([NH:42][C:43](=[O:45])[CH3:44])[CH:37]=2)[CH:33]=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[C:32]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([NH:42][C:43](=[O:45])[CH3:44])[CH:37]=2)[CH:33]=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:5])[CH3:4]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668574HCID 18668574, compound

Product 1

HCID 178474121HCID 178474121, compoundYield 68.3%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-{3′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1′-biphenyl]-3-yl}acetamide (0.781 g) and pyridine hydrochloride (290 mg), the title compound (315 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-fc9b0a91060d41a48dc231fecb4c6631
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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