Acetic Anhydride → N-(6-bromopyridin-2-yl)acetamide

HRID 1059237Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[Br:8][C:4]1[N:3]=[C:2]([NH:1][C:9](=[O:11])[CH3:10])[CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 3008092-Amino-6-bromopyridine

Product 1

HCID 10353221N-(6-bromopyridin-2-yl)acetamide

Procedure

By the reaction in the same manner as in Example 56-(i) using 2-amino-6-bromopyridine (2.97 g) and acetic anhydride (2.9 ml), the title compound (2.30 g) was obtained as colorless scaly crystals.

Sources & evidence

ORD record: ord-9c63cf93820c43fabe768b9cba998a87
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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