Pyridinium chloride → HCID 178474326, compound

HRID 1059244Notes

Reaction equation

[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[C:40]([NH:42][C:43](=[O:45])[CH3:44])[CH:39]=[CH:38][N:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:41]=[C:40]([NH:42][C:43](=[O:45])[CH3:44])[CH:39]=[CH:38][N:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:4])[CH3:5]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 18668540HCID 18668540, compound

Product 1

HCID 178474326HCID 178474326, compoundYield 43%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-(2-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-4-pyridyl)acetamide (0.590 g) and pyridine hydrochloride (190 mg), the title compound (150 mg) was obtained as colorless powder crystals.

Workup

customBy the reaction in the same manner as in Example

Sources & evidence

ORD record: ord-90dc3c7462264da58e301023ea8c6584
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518257B1

Reaction notes

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