Pyridinium chloride → HCID 178464755, compound

HRID 1059247Notes

Reaction equation

HRID 1059247 reaction equation
[CH2:1]([NH:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([OH:46])([C:22]3[N:23]=[CH:24][N:25](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:26]=3)[CH:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)[N:7]=1)=[O:5])[CH3:2].Cl.N1C=CC=CC=1>>[CH2:1]([NH:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([OH:46])([C:22]3[N:23]=[CH:24][NH:25][CH:26]=3)[CH:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)[N:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668590HCID 18668590, compound

Product 1

HCID 178464755HCID 178464755, compoundYield 51.2%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-ethyl-6-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-2-pyridinecarboxamide (1.82 g) and pyridine hydrochloride (570 mg), the title compound (560 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-3f9bd3c519b74e0ba5c9c5d2de5cc922
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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