Pyridinium chloride → HCID 178457681, compound

HRID 1059250Notes

Reaction equation

HRID 1059250 reaction equation
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[N:41]=[C:40]([C:42]([NH:44][CH:45]([CH3:47])[CH3:46])=[O:43])[CH:39]=[CH:38][CH:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[N:41]=[C:40]([C:42]([NH:44][CH:45]([CH3:47])[CH3:46])=[O:43])[CH:39]=[CH:38][CH:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:4])[CH3:5]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 186686356-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-N-isopropyl-2-pyridinecarboxamide

Product 1

HCID 178457681HCID 178457681, compoundYield 35.9%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 6-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-N-isopropyl-2-pyridinecarboxamide (1.60 g) and pyridine hydrochloride (770 mg), the title compound (350 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-73fe3beed19844448c1779b065f1a2dc
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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