HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-N-methylisonicotinamide → 2-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-N-methylisonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-N-methylisonicotinamide | HCID 2762473 | — |
| Reactant | 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid | HCID 18668578 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 2-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-N-methylisonicotinamide | HCID 18668636 | 56.2% |
Reaction Steps
By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (1.30 g), 2-bromo-N-methylisonicotinamide (310 mg) and tetrakis(triphenylphosphine)palladium(0) (0.110 g), the title compound (480 mg) was obtained as a colorless amorphous powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518257B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-d879e6711ea34fe8b521411fc5b319b8 |
| Source note | uspto-grants-2003_02 |