Pyridinium chloride → HCID 178485297, compound

HRID 1059260Notes

Reaction equation

HRID 1059260 reaction equation
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[S:40][C:39]([C:41]([NH:43][CH3:44])=[O:42])=[CH:38][CH:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[S:40][C:39]([C:41]([NH:43][CH3:44])=[O:42])=[CH:38][CH:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:4])[CH3:5]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668576HCID 18668576, compound

Product 1

HCID 178485297HCID 178485297, compoundYield 93%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 5-[4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl]-N-methyl-2-thiophenecarboxamide (1.39 g) and pyridine hydrochloride (484 mg), the colorless amorphous title compound (769 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-f74ad71aefc54255b95e223021d134a1
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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