反应详情

温度

-5 °C

415 g of methyl 10H-pyrazino[2,3-b][1,4]benzothiazine-8-carboxylate was suspended in 2.5 l of N,N-dimethylformamide in a nitrogen atmosphere. Then 66 g of sodium hydride (oily: 60% or more) was added in portions thereto while maintaining the mixture at −10 to 0° C. Then the resulting mixture was stirred for 1 hour. Next, 110 g of chloromethyl methyl ether was dropped thereinto while maintaining the mixture at a temperature not exceeding 5° C. After the completion of the reaction, the reaction mixture was poured into ice, extracted with methylene chloride twice, washed with water and dried over anhydrous sodium sulfate. After distilling off the solvent under reduced pressure, diisopropyl ether was added to the residues and the crystals thus precipitated were taken up by filtration to thereby give 335 g of the title compound as yellow crystals.

1. temperaturewhile maintaining the mixture at a temperature not
2. customexceeding 5° C
3. customAfter the completion of the reaction
4. additionthe reaction mixture was poured into ice
5. extractionextracted with methylene chloride twice
6. washwashed with water
7. dry with materialdried over anhydrous sodium sulfate
8. distillationAfter distilling off the solvent under reduced pressure, diisopropyl ether
9. additionwas added to the residues
10. customthe crystals thus precipitated
11. filtrationwere taken up by filtration