Methyl 6-chloro-5-nitronicotinate → HCID 178498866, compound

Participants

Reaction Steps

To a solution of 6 g of methyl 6-chloro-5-nitronicotinate in methanol (100 ml) was added 6.7 g of sodium hydrogensulfide and the resulting mixture was heated under reflux for 2 hours. After distilling off the solvent under reduced pressure, dilute hydrochloric acid was added to the residue followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. Diisopropyl ether was added to the residue and the crystals thus precipitated were taken up by filtration to thereby give 24.7 g of the title compound as yellow crystals.

Provenance & Evidence