Ammonia → HCID 18670652, compound

Participants

Reaction Steps

To a solution of 2.7 g of methyl 2-methoxy-4-(2-chloropyrazin-3-yl)thio-5-nitrobenzoate in tetrahydrofuran (100 ml) were added 50 ml of a saturated aqueous solution of sodium hydrosufide and 30 ml of 27% aqueous ammonia and the resulting mixture was vigorously stirred at room temperature for 1 hour. Then the reaction mixture was extracted with ethyl acetate and the organic layer was dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, a solution of the residue in tetrahydrofuran was stirred at 70° C. for 1 hour. After distilling off the solvent under reduced pressure, dichloroemthane was added to the residue. The crystals thus precipitated were filtered to thereby give 1.9 g of the title compound as red crystals.

Provenance & Evidence