Lithium borohydride → HCID 18670501, compound

Participants

Reaction Steps

To a solution of 0.19 g of methyl 4-cyano-10-(methoxymethyl)-10H-pyrido[3,2-b][1,4]-benzothiazine-8-carboxylate in dry tetrahydrofuran (5 ml) was added in a nitrogen atmosphere a solution of 0.026 g of lithium borohydride in tetrahydrofuran (10 ml) and the resulting mixture was heated under reflux for 20 minutes. After bringing back to room temperature, the mixture was extracted with 15 ml of water and 15 ml of acetic acid and dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol) to thereby give 0.12 g of the title compound as a pale yellow solid.

Provenance & Evidence