Tetrahydrofuran → HCID 11150428, compound

Participants

Reaction Steps

463 mg of 8-[(2-(tert-butyldimethylsilyloxy)ethyl]-10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazine was dissolved in 5 ml of tetrahydrofuran. After adding 1.3 ml of n-tetrabutylammonium fluoride (1.0 M solution in tetrahydrofuran), the resulting mixture was stirred at room temperature for 1 hour and then at 4° C. for additional 13 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluted with n-hexane/ethyl acetate) to thereby give 281 mg of the title compound as a pale orange solid.

Provenance & Evidence