Trimethylsilyldiazomethane → HCID 18670458, compound

Participants

Reaction Steps

To a solution of 1.55 g of 4-[1-(benzyloxycarbonyl)-piperidin-4-yl]phenylacetic acid in methanol (20 ml) was added 13.2 ml of trimethylsilyldiazomethane (2 M solution in hexane) and the resulting mixture was reacted at room temperature for 1 hour. After distilling off the reaction mixture under reduced pressure, the residue was purified by silica gel column chromatography (eluted with n-hexane/ethyl acetate) to thereby give 1.0 of the title compound as a colorless oily substance.

Provenance & Evidence