Potassium Carbonate → Methyl 1-benzylpiperidine-4-carboximidate

関与物質

反応手順

6.1 g of methyl 1-benzylpiperidine-4-carboximidate dihydrochloride was distributed into an aqueous solution of potassium carbonate and ethyl acetate under ice-cooling. The organic layer was extracted and dried over anhydrous sodium sulfate. After distilling off the solvent under reduced pressure, 4.7 g of free methyl 1-benzylpiperidine-4-carboximidate was obtained as a colorless oily substance. A solution of 2.35 g of methyl 1-benzylpiperidine-4-carboximidate and 0.95 g (10 mmol) of methanesulfonamide in dry methanol was stirred at room temperature for 3 days. Subsequently, 1.0 g of palladium-carbon was added to the reaction mixture and the resulting mixture was stirred in a hydrogen atmosphere under atmospheric pressure for 1 hour. The inorganic matters were eliminated by filtering through celite. After distilling off the solvent under reduced pressure, the residue was recrystallized from methanol to thereby give 1.38 g of the title compound as colorless needles.

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