Acetic Acid → HCID 69885061, compound

HRID 1059350Notes

Reaction equation

HRID 1059350 reaction equation
[CH3:1][NH:2][S:3]([CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)(=[O:5])=[O:4].[C:14]([OH:17])(=[O:16])[CH3:15]>[Pt]=O>[C:14]([OH:17])(=[O:16])[CH3:15].[CH3:1][NH:2][S:3]([CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)(=[O:5])=[O:4]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 18670523HCID 18670523, compound

Product 1

HCID 69885061HCID 69885061, compound

Reagents, catalysts & solvents 1

HCID 82844Platinum oxide (PtO)Catalyst

Procedure

500 mg of N-methyl-2-(piperidin-4-yl)ethanesulfonamide was dissolved in 15 ml of acetic acid. After adding 180 mg of platinum oxide, the resulting mixture was subjected to catalytic reduction at room temperature under a hydrogen pressure of 6 atm. After filtering off the insoluble matters, the acetic acid was distilled off under reduced pressure. The crystals thus precipitated were well washed with diethyl ether and dried under reduced pressure. Thus 664 mg of the title compound was obtained as white crystals almost quantitatively.

Workup

  1. customwas subjected to catalytic reduction at room temperature under a hydrogen
  2. filtrationAfter filtering off the insoluble matters
  3. distillationthe acetic acid was distilled off under reduced pressure
  4. customThe crystals thus precipitated
  5. washwere well washed with diethyl ether
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-523c54e69dfc4da8958e724b45c872ac
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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