反应详情

4.7 g of 10H-pyrazino[2,3-b][1,4]benzothiazine-8-acetonitrile was dissolved in 100 ml of ethanol. After adding 2.8 g of potassium hydroxide, the resulting mixture was heated under reflux for 16 hours. After distilling off the ethanol, water was added and the mixture was made weakly acidic with dilute hydrochloric acid followed by the extraction with ethyl acetate and dichloromethane. The organic layer was dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, 3.85 g of the title compound was obtained as yellow crystals.

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 16 hours
3. distillationAfter distilling off the ethanol, water
4. additionwas added
5. extractionfollowed by the extraction with ethyl acetate and dichloromethane
6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
7. distillationAfter distilling off the solvent under reduced pressure