Imidazole → HCID 18670406, compound

Participants

Reaction Steps

To a solution of 0.543 g of 1-(purin-6-yl)ethanol in N,N-dimethylformamide (10 ml) were added 0.27 g of imidazole and 0.598 g of tert-butyldimethylsilyl chloride and the resulting mixture was stirred at room temperature for 15 hours. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol) to thereby give 0.793 g of the title compound as a white solid.

Provenance & Evidence