HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 18670449, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Amino-2-methylquinoline | HCID 81116 | — |
| Reactant | 10-methoxymethyl-8-chloromethyl-10H-pyrazino[2,3-b][1,4]benzothiazine | HCID 11335363 | — |
| Product | HCID 18670449 | HCID 18670449 | 95.1% |
Reaction Steps
Similar to Example 1094, 307 mg of 8-chloromethyl-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine was treated with 354 mg of 2-methyl-4-aminoquinoline in the presence of 91 mg of sodium hydride (60% oily) to thereby give 413 mg of 8-[(2-methylquinolin-4-yl)aminomethyl]-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine as a yellow oily substance. Then this product was deblocked by the same method as the one of Example 9 to thereby give 114 mg of the title compound as, yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518423B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-b69d50c30a6b49f1bc14925d71774a69 |
| Source note | uspto-grants-2003_02 |