10-methoxymethyl-8-chloromethyl-10H-pyrazino[2,3-b][1,4]benzothiazine → HCID 18670305, compound

Participants

Reaction Steps

0.5 g of 10-methoxymethyl-8-chloromethyl-10H-pyrazino-[2,3-b][1,4]benzothiazine and 1.0 g of 4-(2-aminoethyl)imidazole dihydorchloride were treated by the same method as the one of Example 1094 to thereby give 0.7 g of crude 8-[4-(2-aminoethyl)imidazol-1-yl]-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine as a brown solid. This crude product was then treated by the same method as the one of Example 316 to thereby give 0.1 g of N-[2-[1-(10-methoxymethyl-10H-pyrazino[2,3-b][1,4benzothiazin-8-ylmethyl)imidazol-4-yl]ethyl]methanesulfonamide. Further, it was treated by the same method as the one of Example 8 to thereby give 50 mg of the title compound as yellow crystals.

Provenance & Evidence