8-[1-(Pyridin-3-yl)vinyl]-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine → HCID 18670557, compound

HRID 1059407Notes

Reaction equation

HRID 1059407 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([C:9]2[CH:10]=[CH:11][C:12]3[S:17][C:16]4[N:18]=[CH:19][CH:20]=[N:21][C:15]=4[N:14]([CH2:22][O:23][CH3:24])[C:13]=3[CH:25]=2)=[CH2:8])[CH:2]=1.[H][H]>C(O)C.[C].[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([C:9]2[CH:10]=[CH:11][C:12]3[S:17][C:16]4[N:18]=[CH:19][CH:20]=[N:21][C:15]=4[N:14]([CH2:22][O:23][CH3:24])[C:13]=3[CH:25]=2)[CH3:8])[CH:2]=1

Participants

5

Reactant 2

HCID 186703228-[1-(Pyridin-3-yl)vinyl]-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazineHCID 178418361HCID 178418361, compound

Product 1

HCID 18670557HCID 18670557, compoundYield 45.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

0.23 g of 8-[1-(pyridin-3-yl)vinyl]-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine was dissolved in 10 ml of ethanol and then hydrogenated in the presence of 0.056 g of 10% palladium-carbon (moisture content: 50%) in a hydrogen gas stream at room temperature for 26 hours. Thus 0.106 g of the title compound was obtained as yellow crystals.

Sources & evidence

ORD record
ord-cb0f951ee1114e6c9c4bae858223ffa0
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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