HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 23565218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 18670331 | HCID 18670331 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23565218 | HCID 23565218 | 64.7% |
Reaction Steps
150 mg of methyl iodide was added to a solution of 100 mg of (10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)hydroxyacetic acid in N,N-dimethylformamide (8 ml) in the presence of 260 mg of potassium carbonate. After purifying by silica gel column chromatography (eluted with dichloromethane/methanol) and recrystallizing from ethyl acetate/diisopropyl ether, 68 mg of the title compound was obtained as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518423B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-9256be13364447ddb198c520cf324e5a |
| Source note | uspto-grants-2003_02 |